Dr. Koff received his undergraduate degree from Hamilton College and his medical degree from Case Western Reserve University. He completed residency training in Internal Medicine at Brown University. He then completed fellowship training in Pulmonary & Critical Care Medicine at the University of California, San Francisco (UCSF). This included research in the Cardiovascular Research Institute in the laboratory of his mentor, Jay A. Nadel, M.D., and dedicated fellowship training in adult cystic fibrosis and lung transplantation. In 2011, Dr. Koff joined the faculty at Yale University to Direct the Adult Cystic Fibrosis Program and to continue his research that focuses on pulmonary innate immunity. Dr. Koff is Medical Director of Yale’s Center for Phage Biology & Therapy in which he focuses on bacteriophage therapy for multi-drug resistant infections.